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Remodeling homeostasis of tumor microenvironment to suppress tumor progression

Preclinical Combination Data (ALCAR + Alpha-Lipoic Acid) Preclinical studies in aged rats have demonstrated that combining ALCAR with alpha-lipoic acid (ALA) synergistically improves cognitive function more effectively than either compound alone

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IL-10 regulates inflammation by suppressing the production of cytokines such as IL-1, IL-1, IL-6, IL-8, IL-12 and TNF- in activated M and IFN- in T-cells

these advantages may include the ability (in some cases and with certain preferred combinations) to improve the visible signs of aging in human skin (including, for example, fine lines, wrinkles, skin folds, enlarged pores, roughness, dryness, loss of elasticity, loss of volume), improve other skin texture defects such as stretch marks (as caused by pregnancy, trauma or other influences), reduce bags under the eyes (also called puffy eyes), reduce dark (under eye) circles (both caused by thinning of the skin, insufficient blood circulation and slack tissue), and as well to reduce the severity of atrophic skin and mucosa including vulvovaginal atrophy

Among these derivatives, the most potent one is a hybrid of ISA/hydroxamic acid, ((3R,4R,6R,8R, 9R)-8-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl (4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl) benzoyl)- R -alaninate) (Derivative 11, Figure 2K), the IC 50 of which against the cancer cell lines were below 0.3 M (Mo et al., 2024)