Shellfish anaphylaxis stands as the leading cause of food-related fatalities in Australia, as reported by the Australian Bureau of Statistics, and has exhibited a concerning increase over the past decades [34, 35]
It belongs to a class of drugs known as multi-receptor agonists, and its mechanism of action is notably broad: it simultaneously activates three hormone receptors the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
In contrast, autophagy may act as a molecular rheostat within this network: while basal levels of autophagy contribute to cellular homeostasis by clearing damaged mitochondria and limiting apoptotic signaling, excessive or sustained autophagy can deplete intracellular iron-storage proteins and glutathione, ultimately shifting the redox equilibrium toward ferroptosis (Zhou et al
Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation
9, 4441 (2015), Application(s): Autophagy of human macrophages by flow cytometry, Abstract Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells: Z
Yanbo and Zirong, 2006
