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Depletion of H1 promotes oncogenic and self-renewing activity within cells due to decompaction of chromatin and gene activation (Torres et al 2016)

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Oncogene 14:195202 Biggs WH 3rd, Cavenee WK, Arden KC (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

Interestingly, miR-206 expression was higher in the hippocampus, plasma, and CSF of APP/PS1 mice as compared to wild-type (WT) mice, whereas BDNF level was lower in the hippocampal tissue, plasma, and CSF of APP/PS1 mice than in WT mice