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These enzymes are regulated independently, thereby avoiding the risk of a futile cycle (also known as a substrate cycle) that would result if both reactions occurred simultaneously at high rates

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Zhu ZX, Sun CC, Ting Zhu Y, Wang Y, Wang T, Chi LS, et al

Serrano A, Capriotti A, Cavaliere C et al (2015) Development of a rapid LC-MS/MS method for the determination of emerging fusarium mycotoxins enniatins and beauvericin in human biological fluids

In KRAS-mutant cancer cells with or without LKB1 loss, increased expression of SSP genes and high serine synthesis allow the cells to tolerate serine starvation for survival (Kottakis et al., 2016