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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

Some of these proteins targets were also identified as autoantigens frequently recognized by autoantibodies in autoimmune diseases

doi: 10.1002/bab.2289 357 TeowSYLiewKAliSAKhooASBPehSC

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Thus, caspase-8 is suggested to play a key role in the selection of RCD modalities in erythrocytes

Glutathione is one of our first lines of defense, a ubiquitous molecule, that is, present throughout our organism, but it is particularly concentrated at the liver level , where it protects the liver cells from toxic molecules: in this case, Glutathione "binds" to the toxic metabolites, neutralizing them