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In vitro and in vivo studies using brain cortical tissues have reported that the synaptic release of Glu activates metabotropic Glu receptors on astrocytes, which trigger the arachidonic acid pathway (Lee et al., 2022), resulting in a local increase of Ca 2+ at astrocyte end-feet, and ultimately leads to the dilation of nearby arterioles (Maragakis and Rothstein, 2006