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3E and F)

All these cells are paramount and influence fibroblast migration in wound healing, and they have also been shown to be active in the development of fibrosis

Although no clinical trials or studies have directly linked rapamycin or its derivatives to cardiac toxicity in cancer patients, these agents are associated with an increased risk of hyperglycemia, hyperlipidemia, and hypertensionwell-known risk factors for cardiovascular diseases [276]

Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

Statements Author contributions JL, LJ, and YC designed the present manuscript

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