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Requires to be differentiated from Addisons disease No premalignant potential Endocrinopathies causing oral pigmentation Addisons disease Nelsons syndrome Ectopic ACTH production Pregnancy Addisonian pigmentation May arise with any cause of adrenocortical hypofunction (autoimmune, infection, tumour) Typically involves the buccal mucosa May be the only clinical features of adrenocortical hypofunction The pigmentation is secondary to increased ACTH production by the anterior pituitary Addisonian pigmentation Pigmentation is not specific to Addisons however if associated with candidal infection, endocrine studies should be performed Brown or black color is seen in more than 75% of Addisons patients Nelsons syndrome Rare Excess ACTH production and pituitary expansion secondary to bilateral adrenalectomy for Cushings disease

#Diagnostics #HealthcareInnovation #PrenatalCare #AccessibleHealthcare To view or add a comment, sign in Monitoring and timing of delivery in suspected late fetal growth restriction at term - Fitted MLE logistic regression indicating the estimated probability of severe adverse perinatal outcomes in low- and high-risk fetuses as a function of the gestational age To view or add a comment, sign in Monitoring and timing of delivery in suspected late fetal growth restriction at term - Fitted MLE logistic regression indicating the estimated probability of severe adverse perinatal outcomes in low- and high-risk fetuses as a function of the gestational age To view or add a comment, sign in In pregnant women with sickle cell disease, the risk of developing early-onset preeclampsia can be determined by measuring levels of a protein associated with placental function and development, according to research published today in Blood Advances

Along with recurrent metabolic vomiting, some patients with OA and UCDs present with focal neurological signs or cerebral edema

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