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A more reliable technique is to reduce (knockdown) expression of the gene product, which can be achieved with RNA interference therapies that use a cells own machinery for regulating protein expression or with antisense oligonucleotides (ASO)

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It is undergoing Phase III trials to evaluate its safety in treating DED caused by dry eye syndrome (NCT05310422 and NCT04819269)

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Bile acids as metabolic regulators and nutrient sensors

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