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R., Salemi, M., Lowe, A., et al

J Cell Sci 129:36853693 Kennedy JC, Khabibullin D, Hougard T, Nijmeh J, Shi W, Henske EP (2019) Loss of FLCN inhibits canonical WNT signaling via TFE3

Taking a dose of more than 4,000 international units of vitamin D per day for several years may lead to the serum 25(OH)D concentration being in the range of 50 to 150 ng/ml (125 to 375 nmol/L), which may have potential chronic toxicity (172)