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While we understand the comment that MRFs may not be primarily intended for direct patient use, we disagree that they have little utility for patients and the public

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Stage 1: Dimples are still not visible when standing, but appear when the skin is pinched

It's common for arm pain after a vaccine to be more intense at night

SAEs relatedness to the administration of vitamin B 12 or placebo will be judged by the investigator/designee, the Ethics Committee and the DSMB who will have access to all relevant investigations, clinical assessments and if require unblinding allocated interventions

But it's natural to have a few questions before you start