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Furthermore, H 2 O 2 reacts with iron in the Fenton reaction to produce highly reactive hydroxyl radicals that promote lipid peroxidation and cause cell membrane damage and ferroptosis (Koppula et al., 2021a

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In this process, copper binds to lipoylated mitochondrial proteinsprimarily components of the tricarboxylic acid (TCA) cycleinducing protein aggregation and destabilization of ironsulfur cluster-containing proteins

This process assists the body in repairing a variety of tissues, including those of the stomach, intestines, skin, vasculature, nerve cells, and the brain

doi: 10.1038/s41557-021-00882-0 43 MarjonKCameronMJQuangPClasquinMFMandleyEKuniiKet al