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Participants were seated in front of a computer screen at 90 cm distance and were instructed to keep the same right upper limb position (i.e., upper arm and forearm at 90 angle and hand extended) whenever using the dynamometer (see Supplementary Figure 3A)

The slide images were captured by an inverted microscope and the average optical density (AOD) was measured using Image J 1.53t software

6 Discussion An increasing body of research evidence indicates a close association between hypoxic microenvironments and the occurrence and development of various AIDs, including RA, SLE, MS, DM, SS, and AS

*Correspondence: Jihang Chen, [email protected]

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This process involves the combination of two molecules or molecular fragments to form a higher-order structure via non-covalent interactions or covalent bonds, enabling the rapid construction of complex molecular architectures with diverse physiological properties 3,4