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Keap1 functions as an interacting partner of Nrf2, binding with Nrf2 to facilitate its degradation and exert a negative regulatory influence on Nrf2 activity

Introducing exogenous probiotic strains can modify the homeostatic balance of resident gut microbial communities, potentially eliciting unforeseen immunological effects

Recent studies show that elevated ratios of aspartate to alanine transaminases (AST/ALT or GOT/GPT) correlate with a poor prognosis in bladder (144), colorectal (145), hepatic (146), head and neck (147), oral and oropharyngeal (148), prostate (149), and pancreatic (150) cancers

Nevertheless, clinical translation remains the rate-limiting step

erinaceus sporophores is still controversial, even though oral sporophore supplementation exerted a nootropic action in pilot clinical trials, as reported in the Section 8 [72,73,74]

Several non-clinical and clinical research studies have investigated the influence of non-enzymatic, enzymatic, and natural antioxidants on preventing various diseases [21]