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Lactate can move in and out of cells via MCTs, enter mitochondria to take part in the TCA cycle or be reprocessed in the liver through the Cori cycle

Egerton A, Brugger S, Raffin M, Barker GJ, Lythgoe GJ, McGuire PK, et al

L.EspinozaJ

Nat Commun 9(1):3001 Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M et al (2016) Ruscogenin attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway

(2025) demonstrated that chronic oxidative stress disrupts the balance of gut microbiota and associated metabolites, with these disruptions closely tied to impaired Asp metabolism

By combining these data from a total of 25 tumors over 2 different studies, we performed a comparative analysis of in vivo metM-Wnt lung DIO and control gene expression data utilizing the Hallmark gene sets for GSEA [33]