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Ferroptosis suppressor protein 1 (FSP1) functions independently of GSH/GPX4 by reducing coenzyme Q10 (CoQ10) to its antioxidant form, CoQH 2 , which directly quenches lipid radicals in the plasma membrane ( Another key layer of defense is governed by the transcription factor nuclear factor erythroid 2related factor 2 (NRF2)

Fasting, a conserved determinant of aging, improves disease outcomes and extends lifespan, yet the relative contributions of lipid catabolism versus its attenuation to fasting-induced longevity remain unresolved

1 Introduction Pulmonary fibrosis is a chronic pulmonary disease characterized by the progressive accumulation of extracellular matrix (ECM) proteins, resulting in the formation of scar tissue and thickening of connective tissue, and the pathological process is often accompanied by persistent tissue inflammation ( In recent years, emerging research of healthy diet and nutrition interventions in preventing or alleviating various chronic diseases leading to substantial pharmaceutical investments

Acknowledgements This work is supported by the National Natural Science Foundation of China (nos

Research on polymeric NPs has focused primarily on HA and PLGA NPs

doi: 10.1021/bi001088w