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Similarly, a study using diffusion tensor imaging to assess white matter microstructure in pediatric concussion also failed to find differences in white matter microstructure at 11 days following injury 12 , although another study found higher mean diffusivity in the thalamic radiation 3 months post-injury and reductions in mean diffusivity of the arcuate fasciculus at 6 months post-injury 13

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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications

The expression levels of SLC7 A11 and GPX4 mRNA and protein in pregnant rats in the p53 +/+ group were lower than those in the p53 / group and the PE group, while the expression levels of SLC7 A11 and GPX4 mRNA and protein in pregnant rats in the p53 / group were greater than those in the p53 +/+ group and the PE group, indicating that PE rat models with different expression levels of p53 were successfully constructed

Research emphasizes the importance of the endocannabinoid system (ECS) in neurotrophic factor signaling during fetal CNS development, regulating synaptogenesis, axon growth, neuronal cell fate, migration, and proliferation, as well as neuroprotection mediated by CB1R and BDNF, preventing neuronal death, and the ECSs influence on dopaminergic systems (primarily through D2 receptors), GABAergic, and glutamatergic systems (163)

Data presented as mean standard deviation