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Indeed, several in vitro investigations 42 have reported that the MSC coculture with NP cells was associated with an increase of cell proliferation and ECM synthesis, 43,44 with a reduction of cell senescence and metalloproteinase levels

, Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials, Lancet , vol