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There have been many documented cases of individual vegans developing overt B12 deficiency symptoms after a period of not supplementing (see Individual Cases of B12 Deficiency in Vegans)

When used in conjunction with a healthy diet and exercise program, they can result in significant weight loss

Patients with a sluggish metabolism or difficulty losing weight despite lifestyle efforts

Earlier shorter trials reported small statistically significant differences but the effect sizes were modest

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Biochimie 84 : 975980 Albert SG and Mooradian AD (2004) Low-dose recombinant human growth hormone as adjuvant therapy to lifestyle modifications in the management of obesity