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Description

N.LodhiA.RaiS

van Erp, Christopher R

Distinguished from the structure of apo-PhoP, a symmetric receiver domain dimer connects to a tandem effector domain dimer [317], a new conformation of the PhoP-DNA complex has been found [325]

Environmental and microbial agents have long been implicated as potential triggers in genetically susceptible individuals

Additionally, ROS promotes pro-inflammatory signaling (e.g., NF-B activation) and endothelial adhesion molecule expression (e.g., VCAM-1, ICAM-1, TNF-), further exacerbating vascular stiffness and atherosclerosis (Zeng and Yang, 2024)