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If you are looking at B12 injections, the most useful starting point is the NHS treatment pathway, because it is built around how the body uses and stores B12 rather than around how often a top-up feels nice to have

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[2] Symptoms of deficiency include fatigue, weakness, pale skin, shortness of breath, and neurological disturbances such as paraesthesia, ataxia, and cognitive changes

In my thighs I almost always get lumps and bruises

Another example: individuals with chronic alcoholism often need prolonged thiamine/B-complex support