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Classic payloads in approved ADCs include microtubule-disrupting agents (like auristatins and maytansinoids) and DNA-damaging agents (like calicheamicin or pyrrolobenzodiazepine dimer)

Other mechanisms include upregulation of ABCG1, LDL-R, LXR, PPAR and downregulation of SREBP-1 expression, all inhibiting cholesterol synthesis and accumulation (Khound et al

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