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Mild nausea and changes in bowel habits affect approximately 20-30% of users but typically resolve within 2-3 weeks

Patients with this type of bile acid diarrhea have significantly lower FGF19 and higher 7a-hydroxy-4-cholesten-3-one (C4) levels than healthy controls (169), which supports the hypothesis that excess synthesis of bile acids may overflow the reabsorption capacity in the ileum and hence allow bile acids to enter the colon in larger quantities

Trabectedin use in soft-tissue sarcoma patients in a real-world setting: Data from an Italian national drug-access registry

The first cohort [MSKCC, J Clin Oncol 2018] was comprised of 240 advanced NSCLC patients with mutational data who received ICI therapy (pembrolizumab/pembrolizumab + ipilimumab), and 86 of them accepted PD-L1 expression assessment (Rizvi et al

Answer: Epithalon is generally described as well tolerated in the available research, but it is not FDA-approved as a drug, long-term human safety data are limited, and it should only be used under medical supervision

D.KinouchiT.YajimaM.et al (2009)