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Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta)

At 0 C., to a mixture of (6R)-3-(5-(difluoromethoxy)-2-fluorophenyl)-N-(3-methyl-1,1-dioxidothietan-3-yl)-1-(2-oxocyclopentyl)-4,5,6,7-tetrahydro-1H-indazole-6-carboxamide (66 mg, 0.13 mmol) in MeOH (1.2 mL) was added sodium borohydride (14 mg, 0.38 mmol)

Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers

It also participates in the energy metabolism of the cell (209)

Surgical Pathol

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