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This mechanism is relevant in SLE, where there is excessive NETosis that acts to promote injury and disease development (93)

As stated, glutathione production is upregulated during a toxic exposure

Establishment of ferroptosis-related key gene signature and its validation in compression-induced intervertebral disc degeneration rats

J Leukoc Biol 52:135142 Blomberg OS, Spagnuolo L, Garner H, Voorwerk L, Isaeva OI, van Dyk E, Bakker N, Chalabi M, Klaver C, Duijst M et al (2023) IL-5-producing CD4(+) T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

Conclusions and Perspectives For a long time, H 2 O 2 has been considered not only a simple by-product of oxidative stress in plants but also a molecule involved in the regulation of gene expression during the exposure of plants to biotic and abiotic stresses [9,80,81]

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