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Note: AICAR is provided for Laboratory Research Use Only

Originally developed as antimalarial drugs, these compounds inhibit autophagy by blocking autophagosome-lysosome fusion, thereby preventing the degradation of autophagic cargo

Treatment depends upon the condition that is being treated and the recommendation of the veterinarian and dosing can be varied depending upon the effectiveness and side effects noticed

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However, lower doses of 2APB were ineffective in normalizing elevated Cx32 levels in hepsin / mice, indicating limited therapeutic efficacy

However, Milenkovi-Andjlekovi et al