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doi: 10.1111/dth.15709 42

S.StankeyP.LiX.et al (2022)

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Since CD8 + T cells highly express CD36 (a fatty acid transport molecule), Ox-LDL can be internalized by CD8 + T cells, leading to increased lipid uptake by CD8 + T cells and increased intracellular lipid peroxidation, which further triggers ferroptosis in T cells, resulting in decreased expression of IFN- and TNF-, CD8 + T cell dysfunction and tumor immune escape [228, 229]

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