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Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice

Indeed, if there is a methionine deficit, homocysteine can be re-methylated to form methionine, and if there is an adequate amount of methionine, homocysteine is used to produce cysteine (161)

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Given the crucial role of mitochondrial metabolism in NAFLD progression, the application potential of multiple mitochondrial function improvement modalities (including physical exercise, diabetic medications, small molecule agonists targeting Sirt3, and mitochondria-specific antioxidants) in the treatment of NAFLD was evaluated hoping to provide new insights into NAFLD treatment

Glutathione plays a crucial role in antioxidant defense, detoxification, and cellular metabolism regulation