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Whereas the recommendations for the treatment target of dyslipidemia in the general population are being more and more rigorous, the 2013 Kidney Disease: Improving Global Outcomes clinical practice guideline for lipid management in chronic kidney disease (CKD) presented a relatively conservative approach with respect to the indication of lipid lowering therapy and therapeutic monitoring among the patients with CKD

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It preserves lean mass better than either approach, likely due to its effects on insulin signaling and muscle protein synthesis

Additionally, engineered SpCas9 variants, such as the nuclease-deficient dCas9 fused to different effector domains, enable diverse applications