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Since the peak levels after once-daily oral TRT oversuppress the TSH, neither the population TSH reference range nor the patients own premorbid TSH level can be the goal of therapy

10.1016/0378-4274(95)03532-x 170 WuS.ZhangK.LvC.WangH.ChengB.JinY.et al (2012)

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The method is based on the assumption, that the binding of the (pro)drug occurs mainly inside the cells and that estimation of C u,cell indicates the overall unbound drug concentration in the brain intracellular compartment without specifying the distribution to the specific parenchymal cells or subcellular structures