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VSMC ferroptosis is involved in a range of vascular diseases, such as atherosclerosis, vascular calcification, hypertension, aortic aneurysm, aortic dissection, neointimal hyperplasia, intracranial aneurysm, and pulmonary arterial hypertension

interferon gamma (IFN) compromises proliferation of OPCs, while tumor necrosis factor alpha (TNF) induces apoptosis in differentiated OL (Horiuchi et al., 2006