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Navitoclax (ABT-263) targets BCL-2 family proteins but causes thrombocytopenia (limits clinical use)

We suggest early nephrology consultation for patients at increased risk of TLS (for example, those with active leukaemia or high-grade lymphoma, significantly elevated lactate dehydrogenase), before development of AKD, to facilitate timely coordination of care, intensive care unit transfer and initiation of rasburicase and/or KRT when indicated 28,137

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Surprisingly, and in contrast to the lack of effect on metastasis in vivo, we found that inhibition of both HGF and c-MET (over a period of 4 weeks in culture) significantly decreased the invasion of cancer cells into the collagen matrices