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In addition, compounds targeting mitochondrial nitric oxide radicals can effectively inhibit ferroptosis in various cells, indicating that mitochondrial lipid peroxidation plays a key role in ferroptotic OS (Krainz et al., 2016)

10.3390/molecules27041210 303 Mac GiollabhuiN.SlaneyC.HemaniG.Foley

The slope of the absorbance changes was proportional to the GSH concentration

While cytosolic and blood GSH and Cys biochemical species all experience depletion, the model predicts that a single exposure to doxorubicin only results in a minimal perturbation of the antioxidant defence system