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In the absence of intracellular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) not only reacts with nucleophilic groups of cellular proteins resulting in direct hepatocellular damage, but also participates in redox cycling, thereby generating reactive O 2 species ( ROS ) and consequent oxidative stress that greatly enhance APAP-induced hepatotoxicity

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Chemistry and biology of ferritin

Pharmacol Rev 64:421449

Cryo-EM and artificial intelligence visualize endogenous protein community members

Co-culturing ferroptotic cancer cells with dendritic cells (DCs) reveals that ferroptotic cells decrease maturation of DCs and dampen antigen cross-presentation, and hence inhibit adaptive immune response and promote tumor growth [232]