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Serotonin acts on CNS sites that are attributed several psychological effects such as mood, appetite, personality, affect, motor function, sexual activity, sleep induction, and hallucination as well as temperature regulation and vasospasm

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While the concept is in line with improving the key pathobiological defect in neurodegeneration (locus coeruleus degeneration, reduced noradrenergic innervation and decreased L-lactate production), further developments are needed to bring the proposal to a feasible clinical outcome

Hence, the interaction between the gut microbiota and the occurrence of PD will provide a bright future for intervention, especially for the diagnosis and therapy of PD