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The iron toxicity and oxidative damage regulated by the System Xc /GPX4 axis in hepatocytes may control malaria parasite infection, according to an experimental research [238]

With the sub-toxic dose of 0.1 mM, the low gradient of 40 is temporary, with cells rapidly starting to recover the Tpx1-driven gradient of 300, while with the toxic dose of 0.5 mM the gradient collapse is much more sustained and does not recover even after 50 min