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Although this definition has been widely used for over two decades, the definition of oxidative stress will likely evolve and undergo modification in the future

76 Altogether, although many data point towards CDO1 as being a tumour suppressor gene and a putative prognostic marker for cancer outcome, divergent evidence from glioblastoma patient samples highlight the need for more studies to disclose the actual impact of cysteine-derived organic compounds in cancer metabolic rewiring

Although these experimental findings underscore the potential involvement of the lymphatic system in melanoma metastasis, our understanding of the specific mechanisms remains incomplete (183)

Due to the voluntary nature of post-marketing reports, neither a frequency nor a definitive causal relationship can be established