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Am J Physiol Endocrinol Metab 307:E355E364

Krzyszczyk P, Kang HJ, Kumar S, Meng Y, OReggio MD, Patel K, et al

Each animal weighed 330370g, and all were obtained from Ataturk University's Experimental Animal Laboratory at the Medicinal and Experimental Application and Research Centre

It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood