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This has been demonstrated through the ability of intestinal microbes to promote the repair and proliferation of gut barrier components following their innate recognition (Kitajima et al

These nanoparticles encapsulate polyphenols within their matrix or adsorb them onto their surface, protecting them from degradation and allowing for efficient mucosal penetration ( P

The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodessuch as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signalinginto a dynamic immunometabolic network ( Figure 1 )

doi: 10.1016/j.meatsci.2021.108621 106

Salviolone, a bisnorditerpene compound derived from Salvia miltiorrhiza and Salvia paramiltiorrhiza, has been shown to have inhibitory effects on melanoma cells by inhibiting matrix metalloproteinase 2 activity and the STAT3 pathway [41]

New Drugs 129 MannervikB.BoardP