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In the C57BL/6 J mouse model, the extended gestation period and prolonged labor duration associated with advanced maternal age may be linked to altered extensibility of cervical tissue in older mice 122

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Degeneration of oligodendrocytes and OPCs increases with aging (Kohama et al., 2012), leading to increased myelin breakdown, decreased remyelination, fluctuations in the constituents of myelin and ultimate disruptions in WM integrity during normal aging (Hinman et al., 2006)