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1 Introduction Cardiovascular disease (CVD) is the main cause of death of non-communicable diseases worldwide, accounting for about 30% of all deaths (Mahmood et al., 2014)

1, 2 This impairment appears to play a role in the pathogenesis of migraines, since two different nutrients that are essential for mitochondrial energy production (i.e., riboflavin 3 and magnesium 4 ) were each shown in randomized controlled trials in the 1990s to be effective for migraine prophylaxis