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Libraries were prepared with NEB Next Ultra Directional RNA Library Prep Kit (New England BioLabs) and a 100-bp paired-end sequencing was performed on a HiSeq 2,500 (Illumina) at the Johns Hopkins University (JHU) GRCF core facility

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6A,B), suggesting a role of ferroptosis

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106,107 Based on the purpose of improving the efficacy of ASNase in hematological malignancies, expanding the use of ASNase and reducing side effects, a new generation of ASNase is being developed (Tables 1, 2)

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The study found that this treatment could enhance the immune recognition function of CD8 + T cells and reduce the immune escape of tumor cells [110]

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The blood-tumor barrier is characterized by numerous distinct features, including non-uniform delivery and active efflux of molecules all of which further complicates the delivery of anticancer agents (16)

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