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3.Measure the dosage accurately to avoid overdosing or underdosing

Abstract The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine and methylmalonic acid concentrations in understanding the time course and extent of the inhibition of thymidylate synthase (TS) by pemetrexed in the context of a phase I/II combination study with vinorelbine

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Once the affected intestine is removed, the two healthy ends of the intestine are joined back together (called anastomosis)