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13 Neurotransmitter Action: G-Protein-Coupled Receptors Casey Henley G-protein-coupled receptors (GPCRs), also called metabotropic receptors, are membrane-bound proteins that activate G-proteins after binding neurotransmitters

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Nature 603 , 131137 (2022)

This insulin resistance further promotes lipolysis in adipose tissue, releasing excessive FFAs that subsequently induce OS ( In contrast to LEP, the expression of APN is inversely related to the degree of obesity, and usually there is a decreased expression of APN in obese patients ( Figure 2b