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43 A T-cell intrinsic role of NF-B in regulating Th17 responses was initially indicated by a finding that mice with T-cell-specific IKK deletion have impaired T-cell activation and are refractory to the induction of a Th17-dependent autoimmune disease, experimental autoimmune encephalomyelitis (EAE)

For example, Tregs with activated STAT3 can suppress Th17 responses (intestinal inflammation results from its deficiency), and T-bet expression can further suppress T helper 1 (Th1) and CD8+ T cells (49)

Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injury

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