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Notably, the side chain-to-tail cyclized variant demonstrated potent anti-inflammatory activity and effectively reduced bacterial burden in a mouse skin infection model ( Figure 8 4.3 Terminal/side chain modifications N-terminal acetylation and C-terminal amidation ( Figure 9 ) are frequently employed strategies to enhance peptide stability by mitigating proteolytic degradation (Ting et al., 2020a)

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(C) GSH and GSSG assay by spectrophotometer (i) For preparation of KPE buffer, DTNB, NADPH and GR please refer Reagent Setup

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Multiplex IHC identified increased NET expression of pro-fibrogenic tissue factor and IL-17

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