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ACS Nano 17, 1001910032

10.1093/carcin/bgt026 123 SongP.LiS.WuH.GaoR.RaoG.WangD.et al (2016)

How to explore new TCM drugs that may have clinical value for retinal ferroptosis-related diseases based on TCM theory and clinical efficacy, and confirm the clinical efficacy based on reliable data, is a scientific problem that needs to be solved urgently in the research and development of new TCM drugs related to retinal diseases

In non-enzymatic lipid peroxidation, when initial PLOOH (phospholipid hydroperoxides) are generated and not promptly reduced by the enzyme GPX4, they can react with ferrous ions, leading to the generation of alkoxyl and peroxyl radicals through the Fenton reaction

Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients

After 48 h, cells were counted and seeded as single cells, 300 and 600 cells/well for 1919 and 2012.2 cells in normoxia and hypoxia, respectively, and 200 cells/well for 1919 isogenic models in low glucose, followed by re-addition of the treatments