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Vitamin B12 injection effects can include: Soreness or slight bruising where the needle goes in A warm feeling right after the injection Mild headache in some people, which usually passes quickly Rare allergic reactions, which is why a health check happens first Vitamin B12 injection painful is a common worry, but most people describe it as a quick pinch rather than anything severe

Last reviewed: May 20, 2026 Last updated: May 20, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

The news comes more than a week after the companies announced that their vaccine was more than 90% effective and two days after Moderna said preliminary phase three trial data showed its vaccine was 94.5%

This increased oxidative stress may contribute to soreness and symptom severity

Symptoms like fatigue, tingling, or brain fog may indicate a deficiency

(12 September 2020)