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Park JK, Shrivastava A, Zhang C, Pollok BA, Finkbeiner WE, Gibb ER, Ly NP, Illek B (2020) Functional profiling of CFTR-directed therapeutics using pediatric patient-derived nasal epithelial cell models

The beads were washed 4 times with ice-cold RIPA buffer (50 mM HEPES, pH = 7.5, 500 mM LiCl, 1 mM EDTA, 1.0% NP-40, 0.7% Na-Deoxycholate), followed by once with ice-cold TE buffer (with 50 mM NaCl)

Considering that mitophagy can inhibit neuronal necroptosis and pyroptosis, mitophagy plays a protective role against neuron-induced neuroinflammation

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These data support a normal role for insulin signaling, as a determinant of chondrocyte size, which is apparently cannot compensated by local upregulation of IGF-1/IGF-1R

Lett Appl Microbiol 2019