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Thioredoxin Reductase Thioredoxin comprises three main enzymes, including TR1, TR2, and TR3

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This creates elevated catecholamines (anxiety, insomnia, racing heart), elevated histamine (flushing, hives, food reactions), impaired thiopurine drug metabolism, and impaired arsenic detoxification

B12 plays a part in the process that resets neurotransmitters so it may be that this process starts working more efficiently all of a sudden but the brain takes a while to catch up - I think of that as being like listening to an old analogue radio and having it turned up to full volume because the signal is weak

Retinoids can come with side effects for the skin barrier because they increase cell turnover, so its important to support it